http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-601450-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69487d8570c3a4894e36a06df3f42166 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b8ccf3ce9d623df488cc7b8f0898ed77 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c10a42f6cdac4a66435c3de026c7afca |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-69 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-69 |
| filingDate | 1945-01-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1948-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-601450-A |
| titleOfInvention | Manufacture of sulphonamide compounds |
| abstract | Stable compounds having therapeutic properties are obtained by treating sulphathiazole, sulphadiazine, or a sulphadiazine substituted by one or more alkyl groups, e.g. 2-(41-aminobenzenesulphonamido) - 4 : 6 - dimethylpyrimidine, with a benzylamine or benzamidine substituted by an alkylsulphone or sulphonamide group and having the general formula <FORM:0601450/IV(b)/1> wherein R represents an amidino or aminomethyl group and X represents an alkyl or -NH2 group. Reaction is effected by mixing aqueous solutions of the reactants, or salts thereof which, on mixing, produce the reactants. In examples: (1) aqueous solutions of sodium sulphathiazole and p - aminomethylphenyl methyl sulphone hydrochloride are mixed to precipitate a compound of empirical formula C17H20N4O4S3; (2) sodium sulphathiazole and p - amidinophenyl methyl sulphone hydrochloride and (3) sodium sulphathiazole pentahydrate and p-aminomethylbenzene sulphonamide hydrochloride, are mixed in aqueous solution to precipitate compounds having the respective empirical formul C17H19N5O4S3 and C19H16N5O4S3; (4) 2-(41-aminobenzenesulphonamido) - 4 : 6 - dimethylpyrimidine, in 0.25 N. sodium hydroxide is mixed with aqueous p-aminomethylphenyl methyl sulphone hydrochloride; (5) p-amidinophenyl methyl sulphone hydrochloride; and (6) p-aminomethylbenzene sulphonamide hydrochloride to isolate compounds having the respective empirical formul C25H25N0O4S2, C20H24N6O4S2 and C19H24N6 O4S2; (7) aqueous solutions of sodium sulphathiazole and p-sulphonamidobenzamidine hydrochloride are mixed to precipitate a compound having the empirical formula (C16H18N6O4S3)2, H2O. Specifications 544,836, 573,266, 580,884, 583,585 and 584,584 are referred to. |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 33.