http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-599690-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d202e9e866984fe229f6facc38f1d740 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D241-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D241-08 |
| filingDate | 1944-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1948-03-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-599690-A |
| titleOfInvention | Improvements in or relating to the production of pyrazine derivatives |
| abstract | 2-Hydroxypyrazine and 2-aminopyrazine are manufactured by heating the corresponding 3-carboxy derivatives in the presence of a solvent, preferably to 150-190 DEG C. or above and with stirring. The reaction mixture may be worked up by decolourizing it with the aid of a decolourizing black, filtering and adding a solvent such as petroleum ether to precipitate the desired product. In examples, 2-amino-3-carboxypyrazine is heated with liquid petrolatum at 195 DEG C., or with n-butyl phthalate at 215-220 DEG C., or with water at 150 DEG C. in a bomb, or with carbitol acetate or nitrobenzene under reflux, or with quinoline at 215-7 DEG C., or with sulphuric acid at 240-5 DEG C.; or the sodium salt of the acid is heated with sulphuric acid at 240-5 DEG C., or an aqueous solution of the salt is acidified with hydrochloric acid and the mixture is heated to 150 DEG C. in a bomb. In a further example, 2 - hydroxy - 3 - carboxypyrazine is refluxed with carbitol acetate. Specifications 599,688 and 599,689 are referred to. |
| priorityDate | 1943-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.