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filingDate 1944-08-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 1947-03-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-586453-A
titleOfInvention Process for the production of derivatives of nicotinic acid
abstract Nicotinamidoalkane sulphonic acids are prepared by reacting a nicotinyl halide with an amino alkane sulphonic acid of the general formula NHR.(CnH2n)SO3H wherein R is hydrogen, alkyl, aralkyl or aryl and n is an integer not greater than six, in the presence of an acid acceptor, such as a tertiary amine. The aminoalkane sulphonic acid employed may be b - or g -amino propane-a -sulphonic acid, d - aminobutane - a - sulphonic acid, aminopentane-a -sulphonic acid, a -amino isopentane sulphonic acid, N-methyl-taurine, N-dodecyltaurine, N-phenyl-taurine. N-phenyl-g -aminopropane-a -sulphonic acid. In the examples, nicotinyl chloride hydrochloride, prepared from nicotinic acid and thionyl chloride, is reacted with taurine in pyridine to give nicotinyl taurine. The following are prepared in an analogous manner: nicotinyl-N-methyl taurine; g -nicotinamidopropane - a - sulphonic acid and d - nicotinamidobutane - a - sulphonic acid.
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