http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-567438-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ef57ebc9ba1067fce72f406e3943261 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c8b11372cf962859dbbb3bcc63a609a7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fd9f36df06271a59df790e5021907cdc http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cabc85721a56cd88c1b34282f48d417e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 |
| filingDate | 1943-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1945-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-567438-A |
| titleOfInvention | Manufacture of cyclic ketones |
| abstract | 2-Substituted - 3 - ketotetrahydrothiophenes and their 4-carboxylic acid ester derivatives. Compounds of the formula <FORM:0567438/IV/1> in which R represents an alkyl group and X an alkyl, aryl, substituted alkyl or fatty acid ester residue are obtained by reaction of S-(carbalkoxy-methyl)-thiolpropionic acid esters of the formula ROOC.CH2.CH2.S.CHX.COOR1 wherein R and R1 represent alkyl groups and X has the meaning given above, with alkali metals or their amides or alcoholates. The tetrahydrothiophene derivatives, on hydrolysis and decarboxylation, by methods known for the ketonic cleavage of b -ketone esters, yield 2-substituted-3-ketotetrahydrothiophenes of the formula <FORM:0567438/IV/2> wherein X has the meaning given above and may also represent a fatty acid residue. In examples: 2 - methyl - 3 - ketotetrahydrothio - phene and its 4-carbethoxy derivative are prepared from S - (methyl - carbethoxymethyl) - thiolpropionic acid ethyl ester, g -(3-ketotetrahydrothiophene-2) - butyric acid, its ethyl ester and the 4-carbethoxy derivative thereof, from diethyl S - (2 - carbethoxyethyl) - a - thioladipate, and #s- (3 - ketotetrahydrothiophene - 2) - valeric acid and the 4-carbethoxy derivative of its ethyl ester from diethyl S-(2-carbethoxyethyl)-a -thiolpimelate. In each case the condensation is effected by heating with sodium in benzene under reflux. Identification of the acids by the p-phenylphenacyl ester and the benzylthiuronium salt is referred to. The S-(carbalkoxy-methyl)-thiolpropionic acid esters are prepared by reaction of an alkali metal salt of b -thiolpropionic acid with an appropriate a -halogen acid ester or alkali metal salt and esterification of the resulting acid or half-ester. Specification 562,313 is referred to. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2475580-A |
| priorityDate | 1943-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 32.