http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-550040-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72d3e0aea925818209e5c4b1e3bf5bcc http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2ca2e4410855da087e11bf3eea8933fa http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed2dc07d450cd90ebe80d3dcdac144c4 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C311-37 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C311-37 |
| filingDate | 1940-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1942-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-550040-A |
| titleOfInvention | Improvements in or relating to the production of therapeutically effective sulphonamide compounds |
| abstract | 550,040. Sulphonamido compounds. LILLY & CO., E., KHARASCH, M. S., and REINMUTH, O. Nov. 6, 1940, No. 16181. [Class 2 (iii)] Therapeutically useful compounds are prepared by reacting formaldehyde and an unsubstituted mercapto-carboxylic acid or mercapto-sulphonic acid with 4 - p - aminobenzenesulphonamide or a derivative thereof containing in the amide group an hydroxyl group, an hydroxylated lower alkyl group having more than one carbon atom, an # - pyridyl group, a 2 - thiazolyl group or a substituted 2 - thiazolyl group, preferably in the presence of a non-oxidising mineral acid. The products may be converted into their salts with alkali and alkaline earth metals, ammonia, alkylamines, alkanolamines and polymethylenediamines. Examples are given of the treatment of (1) p - aminobenzenesulphonamide, p - aminobenzenesulphonylethanolamide and # - p - aminobenzenesulphonamidopyridine with formaldehyde and thioglycollic acid, and the conversion of the products into their sodium, ammonium, ethanolamine, diethanolamine, propanolamine, isopropanolamine and ethylenediamine salts ; (2) 2 - p - aminobenzenesulphonamido - 4 - methylthiazole, 2 - p - aminobenzenesulphonamidothiazole, 2 - p - aminobenzenesulphonamido - 4 - phenylthiazole and 2- p - aminobenzenesulphonylhydroxamide with formaldehyde and thioglycollic acid, and the conversion of the products into their sodium salts ; (3) p - aminobenzenesulphonamide with formaldehyde and p - mercaptobenzenesulphonic acid, oc - p - aminobenzenesulphonamidopyridine with formaldehyde and # - mercaptopropionic acid, 2 - p - aminobenzenesulphonamido - 4 - methylthiazole with formaldehyde and o - mercaptobenzoic acid, and the conversion of the products into their sodium salts. |
| priorityDate | 1940-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 50.