http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-517143-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e70c0aeade92d7571d955d3b90ea06e |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C233-00 |
| filingDate | 1938-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1940-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-517143-A |
| titleOfInvention | Improvements in or relating to the production of formamide derivatives |
| abstract | 517,143. Formamide derivatives. DU PONT DE NEMOURS & CO., E. I. July 19, 1938, No. 21449. Convention date, July 22, 1937. [Class 2 (iii)] Mono- and dimethyl formamides are prepared by reacting methanol with carbon monoxide and ammonia at 150-300‹C. under a pressure of 300-1,000 atmospheres, and ethanol formamide is prepared by reacting ethylene glycol, carbon monoxide, and ammonia under the same conditions. The reaction is preferably carried out in the presence of a salt of a strong base with a weak acid such as an alkali metal salt of an aliphatic acid, carbonic acid or boric acid which acts as a catalyst. The preferred catalysts are sodium or potassium formate or acetate. The process may be carried out either as a continuous or a batch process. In examples: (1) a methanol solution of liquid ammonia and potassium acetate is heated in a silver-lined autoclave at 243-260‹C. for 1¢ hours at 900 atmospheres pressure of carbon monoxide to give a mixture of monomethyl and dimethyl formamides which were separated by distillation under reduced pressure. (2) The same reactants as in example (1) were heated at 210‹C. for ¢-hour and then at 245‹C. for one hour under the same pressure of carbon monoxide and the product worked up as before. (3) Ethylene glycol liquid ammonia and potassium formate are heated under 900 atmospheres of carbon monoxide at 230‹C. for 2¢ hours to give ethanol formamide. The Specification as open to inspection under Sect. 91 includes also the production of formamide derivatives of the general formula H.CO.NH.R or H.CONR2, where R stands for an alkyl, aryl, or aralkyl group or substitute group by the reaction together of an alcohol, carbon monoxide and ammonia at an elevated temperature such as 150-350‹C. under a pressure of 300-1,000 atmospheres. The alcohols used may be mono- or polyhydric and may be aromatic, adiphatic or alicyclic. Alcohols mentioned include propanol, isobutanol, propylene glycol, glycerol glycollic acid (which yields the amide of N-formyl glycine) and benzyl alcohol. This subject-matter does not appear in the Specification as accepted. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-1000020-B |
| priorityDate | 1937-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 57.