http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-514103-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95849adaba0e61e9f55845a42f202dc1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_232361c9031a709144573276863c462b http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2f2a16407f4312d6864d1141d9dec838 |
| filingDate | 1938-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1939-10-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-514103-A |
| titleOfInvention | Improvements in and relating to the preparation of hippuric acid derivatives |
| abstract | 514,103. Hippuric acid derivatives. GLAXO LABORATORIES, Ltd., BLOUNT, B. K., and RESUGGAN, J. C. L. Feb. 26, 1938, No. 6167. Sample furnished. [Class 2 (iii)] 4-Hydroxy-3:5-diiodo-hippuric acid is prepared by condensing an acyl derivative of p-hydroxy benzoic acid halide with glycine, removing the acyl group and iodinating the resulting phydroxy-hippuric acid with or without previous isolation of the reaction product. Iodinating agents specified are iodine, iodine and caustic soda, iodine chloride or a mixture of sodium iodate and sodium iodide. The condensation is preferably carried out in the presence of a basic substance. The product may be treated with suitable acylating, alkylating, or substituted alkylating agents and are useful in pyelography. In the examples : (1) p-acetoxy benzoic acid chloride is condensed with glycine in the presence of caustic soda and the resulting p-hydroxy-hippuric acid was crystallized and then treated with iodine in caustic soda solution yielding 4-hydroxy-3:5-diiodo-hippuric acid; (2) 3:5-diiodo-4-hydroxy-hippuric acid is treated with acetic anhydride in caustic soda solution yielding 4-acetoxy-3:5-diiodo-hippuric acid ; (3) 3:5-diiodo-4-hydroxy-hippuric acid is treated with dimethyl sulphate in caustic soda solution yielding 3:5-diiodo-4-methoxy-hippuric acid. A sample furnished under Sect. 2 (5) comprises 4-carboxymethoxy-3:5-diiodo-hippuric acid prepared by treating 4-hydroxy-3:5-diiodo-hippuric acid (prepared as in example (1) with chloracetic acid in the presence of caustic soda. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2680133-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2813118-A |
| priorityDate | 1938-02-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.