http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-495251-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8ca76845b27d5c206f989f54289fb496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_501d59e736eb0e4382506baea95c34db http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b4dae7331034b6b26116b7c2f7acb115 |
| filingDate | 1937-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1938-11-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-495251-A |
| titleOfInvention | An improved process for the preparation of nuclear alkylated, aralkylated or arylated derivatives of alkaloids of the morphine group |
| abstract | Nuclear alkylated, arylated or aralkylated derivatives of dihydrothebainones are prepared by treating esters of the enolic form of dihydrocodeinone and its derivatives with organomagnesium halides in a solvent and hydrolysing the products with acid. The products, which contain one hydrocarbon radicle in the nucleus, may be further treated in the same way to introduce a second hydrocarbon radicle. Any free alkyl or aralkyl halide present in the Grignard reagent to be used may be rendered inactive by the addition of a tertiary amine, e.g. trimethylamine. An example is given of the preparation of methyldihydrothebainone by treating a benzene solution of dihydrocodeinone enol acetate with methylmagnesium iodide; dimethyldihydrothebainone is similarly prepared from methyldihydrocodeinone enol acetate. Specification 492,702 is referred to. Samples have been furnished under Sect. 2 (5) of benzyldihydrothebainone and phenyldihydrothebainone, obtained by reacting dihydrocodeinone enol acetate in benzene solution with benzylmagnesium chloride and phenylmagnesium bromide respectively. |
| priorityDate | 1937-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 30.