http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-459131-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7b04f5b6a02051c94d6eaf190b751ed2 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-42 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D215-38 |
| filingDate | 1935-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1936-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-459131-A |
| titleOfInvention | Manufacture of quinoline compounds |
| abstract | Quinoline compounds are made by (1) reacting an alkylene dihalide containing at least two carbon atoms and having its halogen atoms attached to different carbon atoms with two molecules of a primary or secondary diaminoquinoline of the formula <FORM:0459131/IV/1> wherein R1 and R2 stand for H or an alkyl group and X for H or a methyl group (see Specification 414,105); (2) reacting ammonia or a primary alkylamine with an aminoquinoline of the formula <FORM:0459131/IV/2> wherein X stands for H or methyl, R3 for an alkylene radical which contains at least two carbon atoms, and in cases in which it contains more than two carbon atoms may also contain a hydroxyl group, and R1 and R2 stand for radicals capable of being exchanged for a primary or secondary amino group by reaction with ammonia or a primary alkyl amine; (3) reacting 1 mol. of a diaminoquinoline of the formula in (1) above with 1 mol. of an alkylene oxide containing at least three carbon atoms and containing a halogen atom and reacting the product so obtained with 1 mol. of a diaminoquinoline of the formula in (1) above; (4) using in the process of (3) above instead of a compound of the formula in (1) above, a monoaminoquinoline containing in place of the group NHR1 in 4-position, a group capable of being exchanged for a primary or secondary amino group by reaction with ammonia or a primary alkylamine, and reacting the product with ammonia or a primary alkylamine. Exchangeable groups in (2) and (4) above specified are halogen, alkoxy, phenoxy and sulpho. Alkylene radicals specified are --(CH)2--, --(CH2)3--, --(CH2)4--, --CH(CH3).CH2.CH2--, --CH2.CH(CH3).CH2--, --CH2.CH(C2H5)--, --CH2.CH(OH).CH2-- and the n-hexylene radical. In examples, 4.6-diaminoquinaldine is reacted with (1) ethylene dibromide, (2) trimethylene bromide, (3) epichlorhydrin; (4) 4.8-diaminoquinaldine is reacted with trimethylene bromide, and (5) 4-methoxy-6-aminoquinaldine is reacted ethylene dibromide and the product reacted with ammonia in phenol. 4-Methoxy-6-aminoquinaldine is made by reacting sodium methylate with 4-chloro-6-acetylaminoquinaldine. |
| priorityDate | 1935-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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