http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-287147-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_28fd8a2f7ca983e63d38bcf83d182d44 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07G3-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07G3-00 |
| filingDate | 1928-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1928-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-287147-A |
| titleOfInvention | Process for extracting the cardio-active substance of bulbus scillae |
| abstract | 287,147. Chemische Fabrik vorm. Sandoz. March 16, 1927, [Convention date]. Glucosides.-The cardio-active substances are extracted from Bulbus Scillae by means of organic solvents not miscible with water in the presence of water and easily soluble salts. Small quantities of organic solvents miscible with water such as alcohol, methanol and acetone and also aromatic carboxylic acids such as benzoic and salicylic acids may be added to facilitate the extraction. Fresh bulbs may be used for the process or the preserved product obtained by grinding the bulbs with soluble salts and carefully drying at a low temperature. According to examples : (1) fresh Bulbus Scillae is finely ground together with ethyl acetate and sodium phosphate and the resulting aqueous pulp is filtered and pressed. The residue and the aqueous portion of the filtrate are extracted with ethyl acetate and the combined extracts dried with fused sodium sulphate and nearly evaporated to dryness. The residue is washed with ether. (2) fresh dried squill is ground with ammonium sulphate and dried in a vacuum at a low temperature. Water and ethyl acetate are added and the mixture extracted with ethyl acetate containing salicylic acid. The extract is evaporated to dryness, washed with ether to remove salicylic acid, and worked up as before; (3) fresh squill is ground with magnesium sulphate and dried in a vacuum. After further grinding water and chloroform are added and the extraction performed with chloroform containing methanol; (4) fresh squill is ground with water, and filtered and the filtrate saturated with ammonium sulphate. The liquid is repeatedly extracted with ethyl acetate and the extract, after treatment with anhydrous sodium sulphate is worked up as in example 1. Methyl acetate and methylethylketone are also specified as suitable solvents not miscible with water. Specification 199,400 is referred to. |
| priorityDate | 1927-03-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.