| abstract |
A formulation comprising a benzalkonium antimicrobial agent, a cationic emulsifier, one or more moisturising agents, and water. The formulation may be an oil-in-water emulsion (O/W). The cationic emulsifier may be a quaternary ammonium compound of formula: Where R1 is a C12-26 alkyl, R2 is a C1-3 alkyl, C12-26 alkyl, or a C12-26 carboxamide group, R3 and R4 are C-13 alkyl, and X is a pharmacologically acceptable salt anion. The cationic emuslfier may be distearyldimonium, behentrimonium, or palmitamidopropyltrimonium halides. The antimicrobial agent may be benzalkonium halide. The moisturing agent may include an occlusive agent selected from petrolatum, lanolin, mineral oil, polysiloxane, may include a fatty acid emollient, may include a humectant selected from glycerol (glycerine, glycerin), sorbitol, urea, sodium lactate, propylene glycol, polethylene glycol (PEG), hyaluronic acid, and it may comprise an emollient, occlusive agent, and a humentant, which may be isopropyl palmite, petrolatum, and glycerol. The formulation may comprise benzalkonium chloride and distearyldimonium chloride. A preparation method is provided, wherein the cationic emuslifer and moisturising agent(s) are heated to form a lipohilic mixture, added to a spearate heated volume of water, cooled to 40 C or less, and the benzalkonium is added, followed by pH adjustment to pH 3.5-4.5 |