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filingDate 2020-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2021-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-2591193-A
titleOfInvention Genetic variant panels and methods of generation and use thereof
abstract Described herein are methods for generating and using variant panels of clonally expanded cells containing a plurality of introduced genetic variants. These clonally expanded cells can be partitioned such that each individual partition contains a single genetic variant, allowing for the assessment of the outcome of each variant without the confounding effect of background genetic variation. Further, panels of such variants can be used to evaluate nucleic acid repair strategies. Genetic variation can be introduced through the use of genome editing tools, such as CRISPR/Cas.
priorityDate 2019-09-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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