abstract |
A composition for use as an adjunct in orthopaedic surgery, for example in the treatment of i) delayed fracture healing in bone, manifesting as either a delayed or non-union; ii) a fusion procedure anywhere in the skeletal system, such as a, cranial, spinal, foot and ankle or upper limb and iii) for use as a bone void filler and to enhance bone in-filling in situations of bone loss, such as following combat, e.g., blast injuries, or non-combat related trauma such as road-traffic accidents. The composition comprises i) a parathyroid hormone or a derivative thereof, in an amount of 0.1 ng/ml to 50 ng/ml, (ii) one or more osteoclast inhibitors as defined therein and iii) a bone void filler as defined therein in a solid or liquid phase. The composition may further comprise stem cells. Also disclosed is a method of manufacturing said composition and a kit of parts for the manufacture thereof. |