| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42bafb880871970d57dea45639fd1019 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-517
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate |
2016-04-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0048a131a2272f0c5357a738767092f |
| publicationDate |
2020-06-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
GB-2578973-A |
| titleOfInvention |
Cyclopenta[d]pyrimidines and substituted cyclopenta[d]pyrimidines as antitubulin and microtubule targeting agents, monocyclic pyrimidines as tubulin |
| abstract |
A compound of Formula II, and salts thereof: wherein R is hydrogen or an alkyl group having from one to ten carbon atoms, and wherein R3 is a halogen. Preferably, R is methyl or hydrogen. More preferably, R3 is chlorine. Also claimed is a pharmaceutical composition comprising a compound of Formula II or a pharmaceutically acceptable salt thereof. The compounds of Formula II have antitubulin activity and are useful as microtubule targeting agents and targeted antifolates and tubulin and multiple receptor tyrosine kinase inhibition and antitumor agent activity. |
| priorityDate |
2015-04-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |