http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2572259-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6ca17e41eaa1b1a5fe4bcdb2b4752c7f |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-775 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-28 |
| filingDate | 2019-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94384b1156b7564486de265d815a579f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4af36586f394006ec236e5d0964bc08b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d401397b0a76f04056af04ee97ff085 |
| publicationDate | 2019-09-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2572259-A |
| titleOfInvention | Uses of curcumin derivative |
| abstract | Curcumin derivative TML-6, having the following structure: or a pharmaceutically acceptable salt, solvate, hydrate, isotopologue, or prodrug thereof, and optionally a pharmaceutically acceptable carrier or excipient, for use in a method of preventing and/or treating Alzheimer’s disease in a subject in need of such treatment, said method comprising administering to said subject an effective amount of TML-6 or said salt, solvate, hydrate, isotopologue, or prodrug thereof and optionally said pharmaceutically acceptable carrier or excipient. Curcumin derivative TML-6 is a (1E,6E)-1,7-bis(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione wherein the 4 position is substituted with a methyl group and N,N-diethylacetamide. TML-6 may increase apolipoprotein E (ApoE) expression, promote beta-amyloid clearance, inhibit amyloid precursor protein synthesis and/or inhibit inflammation in brain regions, particularly the hippocampus and other frontal regions. A method of identifying a candidate compound which may increase apolipoprotein E expression, promote beta-amyloid clearance, inhibit amyloid precursor protein synthesis and/or inhibit inflammation in brain regions, comprises contacting the candidate compound with AP-2 or PPARα/RXRα binding site of ApoE promoter region and determining if the candidate compound binds to AP-2 or PPARα/RXRα binding site of ApoE promoter region. |
| priorityDate | 2018-03-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 163.