http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2564887-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_55c6682e171463106dcb724243f8b0ba |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C323-49 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C319-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C319-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-096 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-495 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C323-37 |
| filingDate | 2017-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42d4fb15476e873896ca7855881ecffd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be9877883ba23c41934622e8aff5af8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0846ec531c84c869c58a4a54818787f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bd200a1524f67e462c2253f98968ecad |
| publicationDate | 2019-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2564887-A |
| titleOfInvention | New route of synthesis to vortioxetine salts |
| abstract | A process for the preparation of vortioxetine (1-[2-(2,4-dimethyl-phenylsulfanyl)phenyl]piperazine) salts comprising the steps of: reacting 1-X-2-nitrobenzene and 2,4-dimethylbenzenethiol in the presence of a base and a solvent to yield 2,4-dimethyl-1-[(2-nitrophenyl)sulfanyl]benzene and wherein X is a halogen or nitro group; then reacting the 2,4-dimethyl-1-[(2-nitrophenyl)sulfanyl]benzene with thiosulphate in a solvent to yield (2-((2,4-dimethylphenyl)thio)phenyl)sulfamic acid or a salt thereof: followed by reacting the (2-((2,4-dimethylphenyl)thio)phenyl)sulfamic acid with bis(2-Y-ethyl)amine, wherein Y is selected from the group consisting of halogen, tosyl, triflate or mixtures thereof, in the presence of a solvent to yield 4-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine-1-carbaldehyde; and finally reacting the 4-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine-1-carbaldehyde with hydrogen bromide to yield vortioxetine bromide salt. The intermediate compound (2-((2,4-dimethylphenyl)thio)phenyl)sulfamic acid is also claimed. Pharmaceutical compositions comprising vortioxetine for use in the treatment of major depressive disorder (MDD) and generalized anxiety disorder (GAD) are also disclosed. |
| priorityDate | 2017-07-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 103.