http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-255468-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2b3b3d0797371d9deacaa57400522d2d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-20 |
| filingDate | 1926-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1927-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-255468-A |
| titleOfInvention | Improvements in or relating to the production of derivatives of organic amido- or imido-compounds |
| abstract | 255,468. Dicker, S. G. S., (Verein f³r Chemische Industrie Akt.-Ges.). July 14, 1926. Hexamethylenetetramine compounds; bromo derivatives; sulphonic acids; organo arsenic compounds.-Compounds of organic amido and imido compounds with bromacetyl bromide are combined with hexamethylenetetramine, preferably in the presence of an indifferent solvent. Pyridine, quinoline or other tertiary base is added. An example is given according to which equimolecular quantities of pyrrolidine, diethylbarbituric acid or diamidodioxyarsenobenzene and bromacetylbromide are dissolved in chloroform containing pyridine and an equimolecular quantity of hexamethylenetetramine added. The addition product which separates out is soluble in water. The Specification as open to inspection under Sect. 91 (3) (a) describes the combination of therapeutic organic substances in general with hexamethylenetetramine. Preferably the reaction is effected in the presence of a solvent, such as chloroform, carbon tetrachloride and benzol, and at normal or increased temperature. Pharmaceutical substances mentioned are those containing an aliphatically-combined halogen atom; compounds containing alcoholic or phenolic groups, or their esters with halogen-hydrogen acids, nitric acid, sulphocyanic acid, sulphuric acid, alkyl or aryl sulpho acids, halogen fatty acids and aryl sulpho fatty acids; and addition products of amido compounds, imido compounds, hydrocarbons and other organic compounds having displaceable hydrogen atoms with halogen fatty acids. Examples are given of the formation of compounds of hexamethylenetetramine with isoamyl bromide; bromo-camphor; the bromacetyl derivatives of borneol, isoamyl alcohol, guaiacol, thymol. quinine, santalol, and acetoacetic ester; and the benzenesulphonyl ester of borneol. The bromacetyl and benzene-sulphonyl derivatives above-mentioned are produced by the interaction of the compound with bromacetylbromide and benzenesulphochloride respectively in the presence of pyridine. This subjectmatter does not appear in the Specification as accepted. |
| priorityDate | 1926-07-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 61.