| abstract |
A compound of formula I or IA: wherein R1 is an optional substituent; n is 0-4; R2 and R3 are selected from hydrogen and a substituent, or R2 and R3 join together to form an optional substituted ring; X is an anion. The compounds of formula I or IA can be reduced or decyclised to form nicotinamide ribosides or nicotinate ribosides and thus offer a new route to these compounds (see claim 1 for a new route to a compound of formula V or VA from a compound of formula I or IA). In another aspect, the compound of formula I or IA find use in the treatment of aging, stress, cardiovascular disease, cell death, cancer, metabolic disorder, neuronal disease, blood coagulation disorder, weight control, inflammatory disease, flushing, viral infection, fungal infection, dietary deficiency of vitamin B3, pellagra, pellagra-like condition, vitamin B3 deficiency, or a mitochondrial disease or disorder. |