| abstract |
A drug composition for delivery to the suprachoroidal space or supraciliary space comprising a solid or a semisolid elongate body for injection, wherein the solid or semisolid elongate body comprises a drug, and wherein said drug composition comprises a substance that undergoes biodegradation or bioerosion after injection. Preferably the drug composition comprises a plurality of spherical particles comprising the drug and at least one excipient to form the drug particles into the flexible solid or semisolid. More preferably the particles are microspheres further comprising at least one polymer. The drug is preferably dexamethasone, everolimus, sirolimus, fluocinolone or azithromycin and the polymer is preferably polylactic-glycolic acid. The excipient is preferably polyvinylpyrrolidone. The particles may comprise a core of drug with a surface barrier coating. The coating preferably comprises a non-toxic water soluble polymer, a biodegradable polymer and/or a biological material. The elongate body may be flexible, preferably with at least one discrete region of reduced buckling threshold or flexural rigidity. Also disclosed is a self-actuating injection device for said drug composition comprising a distal seal that is penetrable by the needle by the application of pressure on a tissue surface. A method of treatment of an ocular disease is also disclosed. |