| abstract |
Cyclohexenyl compounds of formula (I): wherein R1 is (CR7R7)n-CO2R8 or a 5- or 6-membered heteroaryl; R2 and R3 are H, F or Cl; X is CR7R7, O, S or NR9; R4 is a saturated 4-6-membered cycloalkyl group or a saturated 4-6-membered heterocycloalkyl group having a ring system with 1-2 heteroatoms selected from O, N and S; R5 is azido, hydroxyl, cyano, nitro, alkoxy, -(CR7R7)mNR9R9 or NR6aC(=NR6a)NR6aR6a; R6a is H, C1-4alkyl, aryl, benzyl or C3-6cycloalkyl; R7 is H or C1 4alkyl; R8 is H, C1-4alkyl, aryl, heteroaryl or C3-6cycloalkyl; R9 is H, C(O)R8, C1-4alkyl, aryl, benzyl or C3-6cycloalkyl; n is 0-4; and m is 0-2; may be useful as anti-viral compounds with activity against both wild type and resistant strains of viruses, particularly influenza viruses. Preferred compounds possess a guanidine group at the 5-position. |