| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_72552047591f0e060569ec163a2dbf84
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed2085748d0da898ca204d006a8174a9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-96433
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-323 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-165 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate |
2013-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5ee9833f34b41e9133bad0e4c3863969 |
| publicationDate |
2015-09-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
GB-2523527-A |
| titleOfInvention |
Screen compounds for the modulation of proprotein convertase subtilisin/kexin type 9(PCSK9) |
| abstract |
A cell-based, functional assay incorporating a recombinant gain of function PCSK9 protein comprising mutants D374Y and S127R to identify inhibitors or modulators of PCSK9. The assay is carried out in HepG2 cells and test compounds dissolved 200 fold in DMSO. Also claimed is an inhibitor of PCSK9 together with a statin for the treatment of atherosclerosis, coronary heart disease and type 2 diabetes. The inhibitor may be colchicine. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-108753821-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020010186-A1 |
| priorityDate |
2013-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |