http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2504775-A
Outgoing Links
Predicate | Object |
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assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c82579bd388a872e62f0cc638df99ae3 |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-075 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-054 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0306 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-03 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4703 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0276 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
filingDate | 2012-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_689df0d31ae047e5f459a7a4ad489355 |
publicationDate | 2014-02-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | GB-2504775-A |
titleOfInvention | Transgenic animals with reduced ERF expression and ossification defect |
abstract | The present invention concerns a non-human transgenic animal comprising a modification in its genome which results in the animal exhibiting a level of Erf expression and/or ERF activity which is reduced compared to a wildtype animal, wherein said animal has a defect in ossification. Further provided is a non-human transgenic animal comprising an insertion of a promoter-marker gene cassette in one or both Erf alleles wherein the cassette is present in an intron of Erf and wherein said animal exhibits an expression level of Erf and/or ERF activity which is reduced compared to a wildtype animal. Uses of these animals and of a nonÂhuman transgenic animal comprising a modification in its genome which results in the animal exhibiting a level of expression of Erf and/or ERF activity which is reduced compared to a wildtype animal for producing animals with ossification defects, for identifying treatments and as disease models are encompassed. |
priorityDate | 2012-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 360.