| abstract |
The invention relates to a method for the synthesis of 3,5-dichloroanisole from 1,3,5-trichlorobenzene, that includes: a) reacting the 1,3,5-trichlorobenzene with a methanolate of an alkaline or alkaline-earth metal in a first solvent selected from dimethylsulfoxide and 1, 1, 3, 3-tetramethylurea; b) precipitating the product from step a) into a second solvent that does not belong to substances considered as carcinogenic, mutagenic and/or toxic for reproduction according to Rule (EC) n° 1272/2008 of the European Parliament and of the Council dated 16th December 2008; and c) recovering the precipitate thus obtained. The invention can be used for the synthesis of 1, 3, 5-triamino- 2, 4, 6-trinitrobenzene, with 3, 5-dichloroanisole being an intermediate product. |