| abstract |
A composition for use in the treatment and/or prevention of platelet related conditions or disorders including haematological proliferative disorders, myeloproliferative disorders and thrombotic and vaso-occlusive disorders, wherein the composition comprises a solid support core of substantially water soluble, swellable or insoluble material; an optional preparatory coat present in the range of 0-5% by weight of the composition; a substrate layer comprising a binder present in the range of 0.1-5% by weight of the composition and 50Ág to 10 mg of microparticles of a platelet number reducing agent such as anagrelide or a derivative thereof, wherein at least 90% of the microparticles are 25 microns or less and are present in a form that has a shelf stability of at least 3 months; a release control component present in the range of 0-10% by weight of the composition and effective for the controlled release of the platelet number reducing agent; and an optional finishing coat and/or enteric coating present in the range of 0-10% by weight of the composition. The composition may further comprise a seal coat layer which may dispersed between the substrate layer and the release control component. The composition may be administered together with other therapeutic agents. Methods and pharmaceutical preparations comprising such agents are also provided. |