abstract |
A solid dosage composition comprising (i) omeprazole, (ii) an antacid which is sodium bicarbonate, present in an amount of at least 400mg and (iii) a disintegrant in an amount of from 2 wt% to 6 wt%. The antacid inhibits/prevents degradation of the omeprazole by increasing the pH of the stomach. The disintegrant is preferably croscarmellose. |