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http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-483
filingDate 2008-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2009-08-26-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-2457660-A
titleOfInvention Methods of calibrating a sensor in a patient monitoring system
abstract One method comprises calculating a sensor drift; calibrating (330) the sensor using at least one calibration fluid, e.g. from two time spaced measurements (320) of a known analyte concentration; and periodically updating (340) the calibration based on the sensor drift calculation. In another method, the system comprises means for adjusting an analyte, e.g. gas concentration in a fluid, the method comprising providing a calibration fluid; setting the analyte concentration in the first fluid to a first concentration with said adjusting means; measuring the first analyte concentration with the sensor; setting the analyte concentration in the first fluid to a second concentration with said adjusting means; measuring the second analyte concentration with the sensor; and determining the calibration coefficients for the sensor from the respective measured concentrations. A further method comprises exposing the sensor to a first fluid comprising a first unknown concentration of the analyte; measuring this concentration with the sensor; determining this concentration with an analyser external to the patient monitoring system; providing the sensor with the determined concentration, and determining the calibration coefficients for the sensor from this concentration and the analyte concentration determined by the analyser. At least some of these methods ensure that the period between recalibrations of the sensor is extended, thus reducing the number of disruptions to the sensor monitoring process. They can be used for flow cells in shunt lines, e.g. for arterial blood, of monitoring systems e.g. for diabetic patients or patients under global anaesthetic.
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