http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2454672-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_261820c1464b2ef0a6c572434b633e12 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L2300-0809 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01L3-5055 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0808 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-58 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-583 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-58 |
| filingDate | 2007-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_190e66fb8ec06f743143a5e3d134263f |
| publicationDate | 2009-05-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2454672-A |
| titleOfInvention | Chromogenic protease substrates |
| abstract | A polypeptide comprising a chromogenic amino acid, wherein the chromogenic amino acid is flanked by at least one amino acid to the N- and C-termini, and wherein the amine group of the chromogenic amio acid has a pKa of less than 5, and the amino acid is capable of reacting with a conjugated aldehyde. The chromogenic amino acid may be p-aminobenzoic acid (pABA). A method of detecting a protease using such a polypeptide comprising: cleaving the polypeptide with a protease to create a fragment containing the chromogenic amino acid, reacting a conjugated aldehyde with the fragment to produce a coloured adduct and detecting the coloured adduct, the presence of the coloured adduct being indicative of the protease. A method of making such a polypeptide by synthesising an amino acid dimer comprising one chromogenic amino acid and incorporating the dimer into the remainder of the polypeptide. Also claimed is a synthetic polypeptide comprising at least one chromogenic amino acid. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10197571-B2 |
| priorityDate | 2007-11-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 67.