| abstract |
A method for inhibiting an ADAM (a disintegrin and metalloprotease) protease, comprising inhibiting binding to an integrin-binding loop of a disintegrin domain in the ADAM protease. Also claimed are ADAM protease inhibitors which inhibit binding to an integrin-binding loop of an ADAM protease; such inhibitors may be cyclic peptides and comprise amino acid sequences TSE, KDE, KDM, SNS, ARQ, MGD, DSD, RGD, NAT, KDK, VRQ, ATD and TDD. |