| abstract |
A process for preparing crystalline particles of an active principal in the presence of ultrasonic irradiation, comprising: contacting a solution of at least one solute in a solvent in a first flowing stream with an anti-solvent in a second flowing stream, causing the mixing thereof, wherein the flow rate ratio of the anti-solvent: solvent is higher than 20:1 (preferably up to 1000:1); and collecting the crystals generated. One or more active principals may be present, which may be fluticasone proprionate and salbutamol, or may be an active principal or carrier substance suitable for inhalation therapy. The solvent and anti-solvent may be the same, and also may be held at different temperatures. |