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publicationDate 2007-09-12-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-2435924-A
titleOfInvention Cellular predictive models for steatosis
abstract Methods for generating models for predicting biological activity of a stimulus on a test population of cells are provided. In particular computer-implemented methods for producing models for classifying a hepatocyte or population of hepatocytes according to whether it exhibits steatosis and also cholestasis or phospholipidosis are presented. Also models are produced for classifying stimuli based on hepatoxicity. The methods may involve receiving a set of phenotypic features of the cells or population of cells that have been exposed to stimuli and treated with one or more markers for particular cellular components by automated image analysis. A subset of the cell populations may be identified to be used in generating a model from data associated with the subset.
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