| abstract |
Compounds of formula (G) modulate the activity of 5-lipoxygenase-activating protein (FLAP). <EMI ID=1.1 HE=46 WI=71 LX=637 LY=796 TI=CF> Such FLAP modulators, alone and in combination with other compounds, may be used for treating inflammation and respiratory, cardiovascular and other leukotriene-dependent or leukotriene mediated conditions or diseases. In formula (G): <DL TSIZE=4> <DT>Z<DD>is -[C(R<1>)2]m-[C(R<2>)2]n--[C(R<2>)2]n-[C(R<1>)2]m-O--O-[C(R<1>)2]m-[C(R<2>)2]n--[C(R<2>)2]n-O--[C(R<1>)2]n- or -[C(R<1>)2]n-O--[C(R<2>)2]n- <DT>R<1><DD>is H, CF3, alkyl or two R<1>s are oxo <DT>R<2><DD>is H, CF3, alkyl, OH, OMe or two R<2>s are oxo <DT>Y<DD>is H, aryl or heteroaryl <DT>R<5><DD>is H, halogen, alkyl or alkoxy <DT>R<6><DD>is H or a group as defined herein <DT>R<7> <DD>is an optionally substituted alkyl of formula -L3-X-L4-G1 as defined herein <DT>R<12><DD>is H or alkyl <DT>R<11><DD>is a substituent of formula -L7-L10-G6 or -L7-L10-W-G7 as defined herein provided that it comprises either <SL> <LI>(i) a heteroaryl ring (system) or <LI>(ii) both an aromatic ring (system) and a heterocyclic ring (system) and </SL> </DL> wherein ```alkyl may be cyclic and optionally unsaturated (including aromatic) ```cycloalkyl may be optionally unsaturated (including aromatic) and ```various groups are optionally substituted as defined herein Other indoles of formula (G-I) and (G-II) (as defined herein) are also disclosed. |