| abstract |
A solution of 5-aminoimidazole-4-carboxamide (AICA) riboside, or an analogue, solvate, isomer, tautomer or salt thereof, is formulated with a buffer, for example Tris, phosphate or histidine, to give a pH of 6.5-7.5. The solution is preferably sterilised. Sterilisation may be achieved by lyophilisation or any other suitable method. The solution may be provided as a perfusate solution with the further inclusion of an excipient, and a second therapeutic agent may be included. These solutions are useful in the treatment or prevention or treatment of ischaemic conditions, conditions regulated by adenosine or reduced blood flow to a tissue. Conditions which may be treated include, for example heart attack, stroke, myocardial infarction, arrhythmia, cardiomyopathy, kidney ischemia and hepatic or pancreatic injuries. The solution may be useful for the treatment of such conditions during cardiac surgery such as coronary artery bypass grafting (CABG) and percutaneous transluminal coronary angioplasty (PTCA). A lyophilised composition comprising AICA riboside and a buffer is also outlined, as are kits comprising these compositions and solutions. |