| abstract |
Disease states modulated by glucorticoid metabolism such as liver disease, adipose related diseases, brain disorders such as glucocorticoid associated cognitive decline and mood disturbance and skin disorders such as glucocorticoid associated acne or hirsutism may be treated by modulators of the functional activity of 5 a reduced metabolites. Preferred modulators include indomethacin, finasteride, dutasteride (GI198745) or LY191704. |