| abstract |
A stable pharmaceutical composition comprising an ACE inhibitor or a pharmaceutically acceptable salt or derivative thereof and a C16-C28 glyceride. The preferred ACE inhibitors are susceptible to heat and/or mechanical stress-induced degradation, but may be stabilised using a C16-C28 glyceride. Preferred ACE inhibitors include ramipril, trandolapril and quinapril. The preferred glyceride is glycerol dibehenate. The composition may be useful for the treatment or prevention of cardiovascular disease, coronary heart disease, cerebrovascular disease, peripheral vascular disease, arrhythmia, hypertension, cardiac failure, cardiovascular death, myocardial infarction, stroke or angina. A method of preparing the pharmaceutical composition and a method of providing a stable pharmaceutical composition comprising an ACE inhibitor, or a pharmaceutically acceptable salt or derivative thereof, by incorporating a C16-C28 glyceride are also outlined. |