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publicationDate 2005-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber GB-2408510-A
titleOfInvention A biodegradable tri-block copolymer for drug delivery systems
abstract A thermo-sensitve copolymer of following formula; <EMI ID=3.1 HE=18 WI=99 LX=484 LY=603 TI=CF> <PC>is disclosed; wherein R1 is hydrogen, or -C(=O)-R2; R2 is C7-30 alkyl substituted or unsubstituted with functional groups; R3 is hydrogen, or C1-6 alkyl; and x, y or z individually is an integer greater than 0. The thermo-sensitive copolymers disclosed here are easy to be implanted into a human body through injection for controlled drug release systems or as embolic agents. The subunits in the polymer are chosen among blocks of PEG (polyethylene glycol) and PLGA (poly (lactide - co -glyceride)). The biodegradability is greatly improved and the cytotoxicity of the copolymers is low.
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