| abstract |
Compounds of general formula (I): <EMI ID=1.1 HE=54 WI=55 LX=813 LY=806 TI=CF> <PC>wherein R<1>, R<2>, R<3> and R<4> are hydrogen, halo, C1-C6 alkyl, -O(C1-C6 alkyl), -CON(R<11>)2 , -SOR<11>, -SO2R<11>, -SO2N(R<11>)2, -N(R<11>)2, -NR<11>COR<11>, -CO2R<11>, -COR<11>, -SR<11>, -OH, -NO2 or -CN; ```each R<11> is hydrogen or C1-C6 alkyl; R<5> and R<6> are each hydrogen, or C1-C6 alkyl or together form a C3-C7 cycloalkyl group; R<7> is hydrogen or C1-C6 alkyl; R<8> is an optionally substituted aromatic moiety other than benzothiazole, R<9> and R<10> are each hydrogen, or C1-C6 alkyl or together form a C3-C7 cycloalkyl group; and their pharmaceutically acceptable salts, hydrates, solvates, complexes or prodrugs are useful in the preparation of pharmaceuticals for the treatment of allergic diseases such as asthma, allergic rhinitis and atopic dermatitis. |