| abstract |
Pharmaceutically acceptable preparations comprising one or more 5HT uptake inhibitors with an excipient matrix comprising a homopolymer or copolymer of N-vinyl pyrrolidone in which the 5HT uptake inhibitors are complexed with the homopolymer or copolymer. The 5HT uptake inhibitors are preferably in amorphous form and may be selected from citalopram, venlafaxine, desmethyl venlafaxine, sertraline, fluoxetine and their salts. The homopolymer or copolymer is preferably a polyvinylpyrrolidone or crospovidone. The preparations are suitable for the treatment of a range of diseases which are prevented, ameliorated or eliminated by the administration of a 5HT uptake inhibitor. Such diseases include depression, substance abuse and senile dementia. One or more 5HT uptake inhibitors together with a homopolymer or copolymer of N-vinyl pyrrolidone may be used in the treatment of such diseases. |