| abstract |
A compound of formula (I) <EMI ID=1.1 HE=32 WI=110 LX=701 LY=572 TI=CF> <PC>wherein ```R<1> is alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl, any of which is optionally substituted with R<4>; ```R<2> is alkyl, alkenyl, alkoxy or alkylthio, any of which is optionally substituted with R<5>; ```R<3> is hydrogen, alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl or heteroaryl, any of which is optionally substituted with R<6>; ```each R<4> is the same or different and is alkyl, alkenyl, alkoxy, aryl, -alkyl-aryl, -alkoxy-aryl, -C(O)O- or -C(O)NH-R<6>; ```each R<5> is the same or different and is alkylthio, aryl, heteroaryl, -NHC(O)-R<6>, -NHC(O)O-R<6>, -C(O)NH-R<6>, -C(O)O-R<6> or -heteroaryl-aryl; ```each R<6> is the same or different and is alkyl, alkenyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl, heteroaryl or -alkyl-aryl; or a pharmaceutically acceptable salt thereof. Preferred compounds feature R<3>= hydrogen or cyclopentylmethyl. These compounds act as BACE inhibitors and thus may be useful in the treatment of Alzheimer's Disease. |