| abstract |
A compound, for therapeutic use, of Formula 1 <EMI ID=1.1 HE=44 WI=45 LX=935 LY=576 TI=CF> <PC>wherein U and V represent independently CH or N; ```R1 represents H, C1-8 alkyl, C2-8 alkenyl, C1-4 alkylaryl or C1-4 alkylCO2R1; ```W, X, Y and Z independently represent either bonds or spacer groups; ```R2 represents CO2R1 or a carboxylic acid bioisostere ; and ```R3 represents CO2R1, a carboxylic acid bioisostere or a carbocyclic aromatic ring of up to 10 carbon atoms or a heterocyclic aromatic ring containing one or more heteroatoms selected from O, N, and S, wherein the carbocyclic or heterocyclic aromatic ring is optionally substituted by one or more groups, R4, independently chosen from: ```H, C1-8 alkyl, C2-8 alkenyl, C1-8 alkyl-OH, C1-4 alkylaryl, C1-4 alkylCO2R1, -CO2R1, -CONR1R5, -CN, -CF3, -SO2R1, phenyl, R4-substituted phenyl, halogen, hydroxyl, C1-8alkoxy, arylC1-8alkoxy, -NH2, -NHR1, -NR1R5, NO2 and SR1; ```R5 is H, C1-8 alkyl, C2-8 alkenyl, C1-4 alkylaryl or C1-4 alkylCO2R1; and ```aryl is phenyl or heterocyclyl optionally substituted by C1-4 alkyl, -OH, -OCH3, -CO2R1, halogen or -CF3. |