| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_69df0c0b3d3d93288e5c810e2eb6797e |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6872
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-705 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-705
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate |
2003-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e79d6cdce5bff7392f35da7a6c9c256
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_73a16b13f8bb9b8d477f0dc7c5f1ad0d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b22e582843f3f323c89731021befcf02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a86f1b4e208e861bbac66072ab1af04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f3963908133c983f5f45a1711c3c5deb |
| publicationDate |
2003-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
GB-2389654-A |
| titleOfInvention |
Sodium channel regulators and modulators |
| abstract |
A method of identifying a modulator of a voltage gated sodium channel (VGSC) comprises: <SL> <LI>(a) bringing into contact a test compound, a VGSC and one or more binding partners selected from PAPIN, periaxin and HSPC025 under conditions where the VGSC and the binding partner(s) are capable of forming a complex in the absence of the test compound; and <LI>(b) measuring an activity of the VGSC, wherein a change in the activity of the VGSC relative to the activity in the absence of the test compound indicates that the test compound is a modulator of said VGSC. </SL> Compounds identified in such screening methods are proposed for use in the treatment of VGSC-related conditions, for example in the treatment or prevention of pain. Also provided are methods of enhancing the functional expression of a voltage gated sodium channel (VGSC) in a cell comprising the step of increasing the level of a binding partner of the invention in the cell. |
| priorityDate |
2002-05-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |