| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_114e4423ec77cbc8dab9d0a98909704e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-002
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-004 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12R1-38 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate |
2001-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a1972dd1e31b8fedbf4e79ee43785c91
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ac916557f796d5e37da5a3d61b28325
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ee1ca16b0101c83d17352baeedb5eb5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3b07435a9a98aa496b637aab767d781a |
| publicationDate |
2003-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
GB-2387597-A |
| titleOfInvention |
Stereoselective preparation of 3-hydroxy-3-phenylpropionitrile |
| abstract |
This invention relates to a Chemoenzymatic process for the stereoselective preparation of both (R) and (S) enantiomers of 3-hydroxy-3-phenylpropanenitrile, useful as a key intermediate for synthesis of (S)-fluoxetine, (R)-tomoxetine and cognant compounds, which comprises reacting cyanohydrin with an acetylating agent in the presence of lipase in an organic solvent, followed by separation of (R)-acetate and (S) alcohol, hydrolyzing (R)-acetate in presence K2CO3 in methanol, filtering the reaction mixture and evaporating the solvent to obtain the (R) alcohol. |
| priorityDate |
2001-01-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |