http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2385051-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_095b1430826cda5ed3eb5a99f2a35272 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 |
| filingDate | 2002-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b9a09b69638a14966ae9f4b9d41b2cc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b807c5e3fbed4cbceafc295d53a3b7df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_25f3382740c74406118f60ea3588ba29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b7770a6609e58affeb17e378870250e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_198ccf03fe346b106b3eca42c42c42f6 |
| publicationDate | 2003-08-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2385051-A |
| titleOfInvention | Preparation of 5-substituted-1-(4-fluorophenyl)-1,3-dihydroisobenzofurans |
| abstract | A process for the preparation of a 5-substituted-1-4-fluorophenyl)-1,3-dihydro-isobenzofuran, an intermediate for the manufacture of Citalopram, from a corresponding 5-substituted phthalide comprises carrying out a Grignard reaction on the 5-substituted phthalide in a co-solvent system comprising (i) a 4-fluorophenyl magnesium halide in an ether solvent and (ii) a suitable organic co-solvent to the ether solvent for the 5-substituted phthalide. A process for the preparation of 4-(bromo or cyano)-2-hydroxymethylphenyl-1-(4'-fluorophenyl)methanol from a corresponding 5-substituted phthalide comprises carrying out a Grignard reaction as indicated above to form a hydroxy ketone and reducing the hydroxy ketone with sodium borohydride. The cosolvent is preferably an aliphatic or aromatic chlorinated solvent or an aromatic hydrocarbon. The products are obtained in high yield and purity; and are intermediates in the preparation of Citalopram. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2004020425-A1 |
| priorityDate | 2002-08-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 112.