| abstract |
A delayed release dosage form comprising: a core containing an active agent; and a coating which comprises a water-insoluble film-forming polymer matrix and microparticles dispersed in the polymer matrix, wherein the microparticles comprise a major fraction of a dietary fibre other than amorphous amylose. Preferred dietary fibres for the microparticles include crystalline resistant starches and modified cellulose. The dosage form provides targeted delivery of the active agent to the large intestine by oral administration. The water-insoluble film forming polymer may be a cellulose acrylate or lignin derivative. The dietary fibre may be a plant cell wall material or derivative or a complex polysaccharide such as guar gum xanthan gum gum arabic a carageenan pectin or starch. The active agent may be a pharmaceutical a dietary supplement or diagnostic agent. |