abstract |
An assay for determining the effect of a chemical substance on the phenotype, physiology, behaviour or biochemistry of nematode worms (particularly <I>C. elegans</I>) comprises detecting changes in the movement behaviour of said worms on contact with said substance, the changes in movement behaviour being determined by non-visual detection means. The assay may be conducted in a multi-well format and may be effected in a liquid medium containing a water soluble polymer which prevents the worms from sticking to the wells. |