http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2356199-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1bde28565d28f037e78bf4a67776ee24 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-24 |
| filingDate | 2001-03-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d7a9d0865217cfc10474bf56912d1782 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a50e7c5c0a6e4382eefe1d573b454a43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fab9bd5f2956a73ab96a12ae41662b6c |
| publicationDate | 2001-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2356199-A |
| titleOfInvention | Production of citalopram in pure form |
| abstract | A process for the preparation of the antidepressant drug citalopram of formula <EMI ID=1.1 HE=42 WI=64 LX=762 LY=549 TI=CF> <PC>in which a compound of formula <B>II</B> <EMI ID=1.2 HE=48 WI=68 LX=748 LY=1175 TI=CF> <PC>wherein Z is iodo, bromo, chloro or CF<SB>3</SB>-(CF<SB>2</SB>)<SB>n</SB>-SO<SB>2</SB>-O- n being 0, 1, 2, 3, 4, 5, 6, 7 or 8, is subjected to a cyanide exchange reaction in which the group Z is exchanged with cyanide by reaction with a cyanide source;<BR> the resultant crude citalopram product is optionally subjected to some initial purification and the crude citalopram base is subsequently subjected to a film distillation process;<BR> the resulting citalopram product is then optionally further purified and worked up and isolated as the base or a pharmaceutically acceptable salt thereof. The film distillation removes high molecular weight impurities. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7365216-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7435838-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03072565-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2376945-A |
| priorityDate | 2000-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.