| abstract |
A compound of formula (I): <EMI ID=1.1 HE=31 WI=102 LX=329 LY=908 TI=CF> <PC>wherein R<SB>1</SB> is hydrogen, carboxyl, ethoxycarbonyl, 4-(ethoxycarbonyl)phenyl, 4-(carboxy)phenyl, 2-(carboxy)-thiophen-5-yl, quinoline -5-yl, 4-(quinoline-5-yl)phenyl or 4- (3-oxo-2-azabicyclo[2,2,2]octane-2-yl)-phenyl;<BR> R<SB>2</SB> is hydrogen or allyl;<BR> X<SB>1</SB> and X<SB>2</SB> are each hydrogen or X<SB>1</SB> and X<SB>2</SB> together form an oxo group; and m is 0, 1 or 2;<BR> and the pharmaceutically acceptable salts thereof, have inhibitory activity against squalene synthase and are thus useful for treating hypercholesterolemia. |