abstract |
The invention relates to a class of enantiomerically pure intermediates represented by Formula I, where X is F, Cl, Br, or I, and a novel enantioselective bioreductive process using yeast to form these intermediates, which are useful in the synthesis of endothelin antagonists, and the like. <EMI ID=1.1 HE=31 WI=46 LX=809 LY=1145 TI=CF> |