http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2333293-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc4cd15dbee579bf2da8bc8e45f0b00f |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D219-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C227-18 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-473 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D219-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C227-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-58 |
| filingDate | 1997-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_72fe562fd17ebdc5a9443815dd8d6c0a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27595bd58147f2a512fd9ae8801b36a6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b36599abf2a354dc8647862fa5c86ca4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4508897ad58de2bf11b04f4ea89ba086 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_98b6a6dd296e8a9fa34b55ae0f148055 |
| publicationDate | 1999-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2333293-A |
| titleOfInvention | Process for the preparation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide |
| abstract | A process for producing an acridine carboxamide of formula (I) wherein each of R<SP>1</SP>, R<SP>2</SP>, R<SP>5</SP> and R<SP>6</SP>, which may be the same or different, is hydrogen or an organic substituent, x is an integer of 1 to 6 and Y is N(R) 2 wherein R is C 1 -C 6 alkyl, or a pharmaceutically acceptable salt thereof, which process comprises: (a) cyclising a compound of formula (II) wherein R<SP>1</SP>, R<SP>2</SP>, R<SP>5</SP> and R<SP>6</SP> are as defined above and R<SP>3</SP> is C 1 -C 6 alkyl, aryl or aryl-C 1 -C 3 alkyl, by treatment with a Lewis acid in an organic solvent, to obtain a compound of formula (III) wherein R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP>, R<SP>5</SP> and R<SP>6</SP> are as defined above: (b) treating either (i) the compound of formula (III) as defined above with a primary alkylamine of the formula (IV): NH 2 (CH 2 )x Y, wherein x and Y are as defined above; or (ii) the carboxylic acid, obtainable by hydrolysing the compound of formula (III) as defined above under basic conditions, with a primary alkyl amine of formula the (IV) as defined above in the presence of a suitable coupling agent to obtain a compound of formula (I) as defined above; and (c) if desired converting one compound of formula (I) into another compound of formula (I), and/or converting a compound of formula (I) into a pharmaceutically acceptable salt thereof. The aldehyde of formula (II) is obtained by oxidation of the corresponding alcohol, which in turn is produced by mild reduction of the corresponding carboxylic acid via an immidazolide intermediate. |
| priorityDate | 1996-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 34.