http://rdf.ncbi.nlm.nih.gov/pubchem/patent/GB-2330142-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b0c198757da18cf77dfbdcef00abb70 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K45-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate | 1998-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88364e1aa4f65d384fe3dad247318c34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5f9f27a2d99f220370330c03020eb617 |
| publicationDate | 1999-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | GB-2330142-A |
| titleOfInvention | Interaction between guanine exchange factors (GEF) and G(ß) proteins |
| abstract | There is described a nucleic acid sequence encoding a section of Cdc24p (from Saccharomyces cerevisiae), a GEF, which does not substantially alter the interaction of this protein with the subunit of a hetero-trimeric G protein (G#). Mutant nucleic acid libraries and peptides of Cdc24p which alter the interaction of this GEF and G# are illustrated. The interruption of Cdc24p and G# prevents mating in yeasts but allows vegetative growth. The use of the products to screen for anti-fungal or anti-cancer agents is envisaged. Mutants of the G#, Ste4p, which prevent the interaction of G# and Cdc24p, are illustrated. The binding of the Far1 protein to Cdc24p is described. An assay is described in which the effect of human oncogenes proto-Dbl and Vav on S. cerevisiae with mating defects is assessed. A dbl peptide is also exemplified. |
| priorityDate | 1997-10-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 106.