| abstract |
Novel 5'-deoxy-cytidine derivatives and pharmaceutical compositions thereof, represented by the general formula (I) wherein R<SP>1</SP> is a hydrogen atom or a group easily hydrolyzable under physiological conditions; R<SP>2</SP> is a hydrogen atom, or -CO-OR<SP>4</SP> group [wherein R<SP>4</SP> is a saturated or unsaturated, straight or branched hydrocarbon group consisting of one to fifteen carbon atoms, or a group of the formula -(CH 2 ) n -Y (in which Y is cyclohexyl or phenyl; n is an integer from 0 to 4)]; R<SP>3</SP> is a hydrogen atom, bromo, iodo, cyano, a C 1-4 alkyl group [which may be substituted with halogen atom(s)], a vinyl or ethynyl group [which may be substituted with halogen atom(s), C 1-4 alkyl, cycloalkyl, aralkyl, or aromatic ring which may have one or more hetero atom(s)], or an aralkyl group which may be substituted for use in medical therapy, especially tumor therapy. |